Something that has frustrated me for a while, that I mentioned in my tips on how to speed up your computer, is how the Windows Defrag utility doesn’t defragment the system pagefile or registry.
This is important – because these are two large files that are accessed frequently, hence these files are probably top on the list for defragmentation.
I found a handy post at online-tech-tips that explains how to defragment the pagefile and registry in Windows XP. Go there and take a look.